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KMID : 0363220150530030209
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Korean Journal of Dermatology
2015 Volume.53 No. 3 p.209 ~ p.216
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Vitamin D Status and Its Relationship with Disease Severity/activity in Patients with Atopic Dermatitis, Psoriasis, and Chronic Idiopathic Urticaria in Korea
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Kim Won-Jeong
Kim Jun-Young
Park Min-Young
Song Margaret
Kim Hoon-Soo
Ko Hyun-Chang
Kim Byung-Soo
Kim Moon-Bum
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Abstract
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Background: Deficiency of vitamin D is reported to be an important factor associated with various dermatoses such as atopic dermatitis, psoriasis, urticaria, and skin cancers. However, this association is disputable and has not been clarified.
Objective: To evaluate the status of serum 25-hydroxyvitamin D in patients with atopic dermatitis, psoriasis, and chronic urticaria, and examine the relationship between vitamin D levels and disease severity/activity compared with sex- and age-matched healthy controls.
Methods: A cross-sectional study of 23, 34, and 73 patients with atopic dermatitis, psoriasis, and chronic idiopathic urticaria, respectively, and sex- and age-matched controls was conducted. Objective severity scoring of atopic dermatitis (eczema area and severity index) and psoriasis (psoriasis area and severity index), the urticaria activity score, and serum 25-hydroxyvitamin D levels were measured for each subject.
Results: Serum 25-hydroxyvitamin D levels were significantly lower in atopic dermatitis patients than those in the controls (p＜0.05). However, mean vitamin D levels in psoriasis and chronic idiopathic urticaria patients were not significantly lower than those in the controls (p＞0.05). Furthermore, no significant inverse correlation was found between disease severity and serum 25-hydroxyvitamin D levels in atopic dermatitis, psoriasis, and chronic idiopathic urticaria patients (p＞0.05).
Conclusion: The impact of vitamin D in these dermatoses seems to be overestimated and needs further study to prove any true association. (Korean J Dermatol 2015;53(3):209∼216)
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KEYWORD
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Atopic dermatitis , Chronic urticaria , Deficiency , Psoriasis , Vitamin D
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